Precise surface functionalization of PLGA particles for human T cell modulation

Pierce Hadley, Yuanzhou Chen, Lariana Cline, Zhiyuan Han, Qizhi Tang, Xiao Huang, Tejal Desai

Published: 2023-10-17 DOI: 10.1038/s41596-023-00887-8

PLGA particles

DNA scaffolds

immune cell modulation

bioconjugation

T cell activation

AI 解读

Using high-resolution microscopy data to generate realistic structures for electromagnetic FDTD simulations from complex biological models

Experimental modulation of physiological force application on leg joint neurons in intactDrosophila melanogaster

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility

Identification, isolation and analysis of human gut-associated lymphoid tissues

Development of RNA G-quadruplex (rG4)-targetingl-RNA aptamers by rG4-SELEX

Self-assembled ultraflexible probes for long-term neural recordings and neuromodulation

Hyperpolarized water as universal sensitivity booster in biomolecular NMR

Improved sampling and DNA extraction procedures for microbiome analysis in food-processing environments

An analytical workflow for dynamic characterization and quantification of metal-bearing nanomaterials in biological matrices

A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues

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Tan, S., Li, D. & Zhu, X. Cancer immunotherapy: pros, cons and beyond. Biomed. Pharmacother. 124, 109821 (2020).
Mitchell, M. J. et al. Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 20, 101–124 (2021).
Blanco, E., Shen, H. & Ferrari, M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat. Biotechnol. 33, 941–951 (2015).
Dellacherie, M. O., Seo, B. R. & Mooney, D. J. Macroscale biomaterials strategies for local immunomodulation. Nat. Rev. Mater. 4, 379–397 (2019).
Wang, H. & Mooney, D. J. Biomaterial-assisted targeted modulation of immune cells in cancer treatment. Nat. Mater. 17, 761–772 (2018).
Waldman, A. D., Fritz, J. M. & Lenardo, M. J. A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nat. Rev. Immunol. 20, 651–668 (2020).
Sterner, R. C. & Sterner, R. M. CAR-T cell therapy: current limitations and potential strategies. Blood Cancer J. 11, 1–11 (2021).
Romano, M., Fanelli, G., Albany, C. J., Giganti, G. & Lombardi, G. Past, present, and future of regulatory T cell therapy in transplantation and autoimmunity. Front. Immunol. 10, 43 (2019).
Ferreira, L. M. R., Muller, Y. D., Bluestone, J. A. & Tang, Q. Next-generation regulatory T cell therapy. Nat. Rev. Drug Discov. 18, 749–769 (2019).
Herold, K. C. et al. An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes. N. Engl. J. Med. 381, 603–613 (2019).
Balcerek, J. et al. Polyclonal regulatory T cell manufacturing under cGMP: a decade of experience. Front. Immunol. 12, 744763 (2021).
Dong, S. et al. The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes. JCI Insight 6, e147474 (2021).
Lin, M. J. et al. Cancer vaccines: the next immunotherapy frontier. Nat. Cancer 3, 911–926 (2022).
Larson, R. C. & Maus, M. V. Recent advances and discoveries in the mechanisms and functions of CAR T cells. Nat. Rev. Cancer 21, 145–161 (2021).
Tang, L. et al. Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat. Biotechnol. 36, 707–716 (2018).
Bonati, L. & Tang, L. Cytokine engineering for targeted cancer immunotherapy. Curr. Opin. Chem. Biol. 62, 43–52 (2021).
Hwang, J.-R., Byeon, Y., Kim, D. & Park, S.-G. Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development. Exp. Mol. Med. 52, 750–761 (2020).
Veerman, R. E., Güçlüler Akpinar, G., Eldh, M. & Gabrielsson, S. Immune cell-derived extracellular vesicles—functions and therapeutic applications. Trends Mol. Med. 25, 382–394 (2019).
Chang, J. T., Wherry, E. J. & Goldrath, A. W. Molecular regulation of effector and memory T cell differentiation. Nat. Immunol. 15, 1104–1115 (2014).
Huang, X. et al. DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat. Nanotechnol. 16, 214–223 (2021).
Majedi, F. S. et al. Augmentation of T-cell activation by oscillatory forces and engineered antigen-presenting cells. Nano Lett. 19, 6945–6954 (2019).
Cheung, A. S., Zhang, D. K. Y., Koshy, S. T. & Mooney, D. J. Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells. Nat. Biotechnol. 36, 160–169 (2018).
Rhodes, K. R., Meyer, R. A., Wang, J., Tzeng, S. Y. & Green, J. J. Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction. Acta Biomater. 112, 136–148 (2020).
Kim, J. V., Latouche, J.-B., Rivière, I. & Sadelain, M. The ABCs of artificial antigen presentation. Nat. Biotechnol. 22, 403–410 (2004).
Boozer, C., Ladd, J., Chen, S. & Jiang, S. DNA-directed protein immobilization for simultaneous detection of multiple analytes by surface plasmon resonance biosensor. Anal. Chem. 78, 1515–1519 (2006).
Liu, Y. & Yu, J. Oriented immobilization of proteins on solid supports for use in biosensors and biochips: a review. Microchim. Acta 183, 1–19 (2016).
Bilal, M., Asgher, M., Cheng, H., Yan, Y. & Iqbal, H. M. N. Multi-point enzyme immobilization, surface chemistry, and novel platforms: a paradigm shift in biocatalyst design. Crit. Rev. Biotechnol. 39, 202–219 (2019).
Smith, M. R., Tolbert, S. V. & Wen, F. Protein-scaffold directed nanoscale assembly of T cell ligands: Artificial antigen presentation with defined valency, density, and ratio. ACS Synth. Biol. 7, 1629–1639 (2018).
Wang, X. & Rivière, I. Clinical manufacturing of CAR T cells: foundation of a promising therapy. Mol. Ther. Oncolytics 3, 16015 (2016).
Arcangeli, S. et al. CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome. J. Clin. Invest. 132, e150807 (2022).
López-Cantillo, G., Urueña, C., Camacho, B. A. & Ramírez-Segura, C. CAR-T cell performance: how to improve their persistence? Front. Immunol. 13, 878209 (2022).
Arcangeli, S. et al. Next-generation manufacturing protocols enriching TSCM CAR T cells can overcome disease-specific T cell defects in cancer patients. Front. Immunol. 11, 1217 (2020).
Elmowafy, E. M., Tiboni, M. & Soliman, M. E. Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles. J. Pharm. Investig. 49, 347–380 (2019).
Roybal, K. T. et al. Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. Cell 164, 770–779 (2016).
Maynard, S. A., Winter, C. W., Cunnane, E. M. & Stevens, M. M. Advancing cell-instructive biomaterials through increased understanding of cell receptor spacing and material surface functionalization. Regen. Eng. Transl. Med. 7, 533–547 (2021).
Zhong, J. X., Raghavan, P. & Desai, T. A. Harnessing biomaterials for immunomodulatory-driven tissue engineering. Regen. Eng. Transl. Med. https://doi.org/10.1007/s40883-022-00279-6 (2022).
Mertgen, A.-S. et al. Multifunctional biomaterials: combining material modification strategies for engineering of cell-contacting surfaces. ACS Appl. Mater. Interfaces 12, 21342–21367 (2020).
Bao, G., Mitragotri, S. & Tong, S. Multifunctional nanoparticles for drug delivery and molecular imaging. Annu. Rev. Biomed. Eng. 15, 253–282 (2013).
Saminathan, A., Zajac, M., Anees, P. & Krishnan, Y. Organelle-level precision with next-generation targeting technologies. Nat. Rev. Mater. 7, 355–371 (2022).
Lagreca, E. et al. Recent advances in the formulation of PLGA microparticles for controlled drug delivery. Prog. Biomater. 9, 153–174 (2020).
Yu, W., Liu, R., Zhou, Y. & Gao, H. Size-tunable strategies for a tumor targeted drug delivery system. ACS Cent. Sci. 6, 100–116 (2020).
Pradal, J. et al. Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice. Int. J. Pharm. 498, 119–129 (2016).
Adakkattil, R., Thakur, K. & Rai, V. Reactivity and selectivity principles in native protein bioconjugation. Chem. Rec. 21, 1941–1956 (2021).
Trads, J. B., Tørring, T. & Gothelf, K. V. Site-selective conjugation of native proteins with DNA. Acc. Chem. Res. 50, 1367–1374 (2017).
Saha, B., Songe, P., Evers, T. H. & Prins, M. W. J. The influence of covalent immobilization conditions on antibody accessibility on nanoparticles. Analyst 142, 4247–4256 (2017).
Zamecnik, C. R., Lowe, M. M., Patterson, D. M., Rosenblum, M. D. & Desai, T. A. Injectable polymeric cytokine-binding nanowires are effective tissue-specific immunomodulators. ACS Nano 11, 11433–11440 (2017).
Makaraviciute, A., Jackson, C. D., Millner, P. A. & Ramanaviciene, A. Considerations in producing preferentially reduced half-antibody fragments. J. Immunol. Methods 429, 50–56 (2016).
Sapsford, K. E. et al. Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology. Chem. Rev. 113, 1904–2074 (2013).
Khandare, J. & Minko, T. Polymer–drug conjugates: progress in polymeric prodrugs. Prog. Polym. Sci. 31, 359–397 (2006).
Martínez-Jothar, L. et al. Insights into maleimide-thiol conjugation chemistry: conditions for efficient surface functionalization of nanoparticles for receptor targeting. J. Control. Release 282, 101–109 (2018).
Chiodi, E., Marn, A. M., Geib, M. T. & Ünlü, M. S. The role of surface chemistry in the efficacy of protein and DNA microarrays for label-free detection: an overview. Polymers 13, 1026 (2021).
Pei, X. et al. Putting precision and elegance in enzyme immobilisation with bio-orthogonal chemistry. Chem. Soc. Rev. 51, 7281–7304 (2022).
Wasserberg, D., Cabanas-Danés, J., Subramaniam, V., Huskens, J. & Jonkheijm, P. Orthogonal supramolecular protein assembly on patterned bifunctional surfaces. Chem. Commun. 54, 1615–1618 (2018).
Meder, F., Kaur, S., Treccani, L. & Rezwan, K. Controlling mixed-protein adsorption layers on colloidal alumina particles by tailoring carboxyl and hydroxyl surface group densities. Langmuir 29, 12502–12510 (2013).
Wongrakpanich, A., Khunkitchai, N., Achayawat, Y. & Suksiriworapong, J. Ketorolac-loaded PLGA-/PLA-based microparticles stabilized by hyaluronic acid: effects of formulation composition and emulsification technique on particle characteristics and drug release behaviors. Polymers 15, 266 (2023).
Makadia, H. K. & Siegel, S. J. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 3, 1377–1397 (2011).
Vivek, K., Harivardhan Reddy, L. & Murthy, R. S. R. Comparative study of some biodegradable polymers on the entrapment efficiency and release behavior of etoposide from microspheres. Pharm. Dev. Technol. 12, 79–88 (2007).
Ghasemiyeh, P. & Mohammadi-Samani, S. Polymers blending as release modulating tool in drug delivery. Front. Mater. 8, 752813 (2021).
Fu, J. et al. DNA-scaffolded proximity assembly and confinement of multienzyme reactions. Top. Curr. Chem. 378, 38 (2020).
Wiener, J., Kokotek, D., Rosowski, S., Lickert, H. & Meier, M. Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics. Sci. Rep. 10, 1457 (2020).
van der Sleen, L. M. & Tych, K. M. Bioconjugation strategies for connecting proteins to DNA-linkers for single-molecule force-based experiments. Nanomaterials 11, 2424 (2021).
von Witting, E., Hober, S. & Kanje, S. Affinity-based methods for site-specific conjugation of antibodies. Bioconjugate Chem. 32, 1515–1524 (2021).
Manning, M. C., Chou, D. K., Murphy, B. M., Payne, R. W. & Katayama, D. S. Stability of protein pharmaceuticals: an update. Pharm. Res. 27, 544–575 (2010).
Frokjaer, S. & Otzen, D. E. Protein drug stability: a formulation challenge. Nat. Rev. Drug Discov. 4, 298–306 (2005).
Wang, W. Protein aggregation and its inhibition in biopharmaceutics. Int. J. Pharm. 289, 1–30 (2005).
Themeli, M., Rivière, I. & Sadelain, M. New cell sources for T cell engineering and adoptive immunotherapy. Cell Stem Cell 16, 357–366 (2015).
Stock, S., Schmitt, M. & Sellner, L. Optimizing manufacturing protocols of chimeric antigen receptor T cells for improved anticancer immunotherapy. Int. J. Mol. Sci. 20, 6223 (2019).
Eskandari, S. K. et al. Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter. Sci. Transl. Med. 12, eaaw4744 (2020).
Ghaffari, S. et al. Optimizing interleukin-2 concentration, seeding density and bead-to-cell ratio of T-cell expansion for adoptive immunotherapy. BMC Immunol. 22, 43 (2021).
Schneider, C. A., Rasband, W. S. & Eliceiri, K. W. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9, 671–675 (2012).
Wang, Y. et al. Phase transitions in human IgG solutions. J. Chem. Phys. 139, 121904 (2013).
Wang, S. S., Yan, Y. S. & Ho, K. US FDA-approved therapeutic antibodies with high-concentration formulation: summaries and perspectives. Antib. Ther. 4, 262–272 (2021).
Vincent, M. P., Navidzadeh, J. O., Bobbala, S. & Scott, E. A. Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy. Cancer Cell 40, 255–276 (2022).
Danaei, M. et al. Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics 10, 57 (2018).
Fass, D. & Thorpe, C. Chemistry and enzymology of disulfide cross-linking in proteins. Chem. Rev. 118, 1169–1198 (2018).
Delcassian, D., Sattler, S. & Dunlop, I. E. T cell immunoengineering with advanced biomaterials. Integr. Biol. 9, 211–222 (2017).
Wang, C., Sun, W., Ye, Y., Bomba, H. N. & Gu, Z. Bioengineering of artificial antigen presenting cells and lymphoid organs. Theranostics 7, 3504–3516 (2017).
Si, X., Xiao, L., Brown, C. E. & Wang, D. Preclinical evaluation of CAR T cell function: in vitro and in vivo models. Int. J. Mol. Sci. 23, 3154 (2022).

Precise surface functionalization of PLGA particles for human T cell modulation

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