Co-fractionation–mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain

Mara Zilocchi, Matineh Rahmatbakhsh, Mohamed Taha Moutaoufik, Kirsten Broderick, Alla Gagarinova, Matthew Jessulat, Sadhna Phanse, Hiroyuki Aoki, Khaled A. Aly, Mohan Babu

Published: 2023-11-19 DOI: 10.1038/s41596-023-00901-z

mass spectrometry

proteomic sample preparation

mitochondrial protein assemblies

neuronal function

PPI networks

AI 解读

Supplementary information

Reporting Summary

Supplementary Data 1

High-quality mt protein interactions predicted in mouse brain.

Supplementary Data 2

Mt protein complexes derived from protein interactions in mouse brain.

Supplementary Data 3

Mt subunits of putative protein complexes enriched for GO annotations, human disorders and phenotypic aberrations in human disease.

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Co-fractionation–mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain

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