Tissue perfusion parameter-guided initial resuscitation in adult patients with sepsis or septic shock: A systematic review and network meta-analysis
Tomoki Kuribara, Tetsuya Yumoto, Kohei Yamada, Takehito Sato, Shigeru Koba, Kenichi Tetsuhara, Masahiro Kashiura, Masaaki Sakuraya,MD, MPH
Abstract
Background: Hemodynamic management is crucial in treating patients with sepsis or septic shock. To date, several tissue perfusion parameters have been suggested, however; the optimal parameter is not well defined.
Objective: This study aims to examine whether and which tissue perfusion parameter-guided therapy during initial resuscitation in adult patients with sepsis or septic shock improved patients’ outcomes.
Design: Systematic review and network meta-analysis.
Data sources: We will search the following electronic bibliographic databases: Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE via PubMed, Web of Science, and Igaku-Chuo-Zasshi. We will also search the World Health Organization International Clinical Trials platforms Search Portal (ICTRP) and ClinicalTrials.gov. for ongoing trials. There will be no language restriction.
Analysis: We will have two types of meta-analysis planned. First, direct pairwise meta-analysis will be conducted using random effect models. Second, network comparison meta-analysis will be conducted using a frequentist approach with multivariate random effect meta-analysis.
