Diagnostic value of PD-L1 ≥ 1% expression status and its efficacy correlation with PD-1/PD-L1 inhibitor therapy in advanced solid cancers: a meta-analysis
Anonymous
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Abstract
Despite immune checkpoint inhibitors (ICIs) seem to have found their role in several hematological and solid tumors, several questions remain unanswered. Among these, the lack of validated biomarkers of response represents an important issue since only a proportion of patients benefit from immunotherapy. Based on these premises, a greater understanding of the role of potential biomarkers including programmed death ligand 1 (PD-L1) expression, tumor mutational burden (TMB), microsatellite instability (MSI) status, gut microbiota and several others is fundamental. In addition, clinical trials on immunotherapy widely differed in terms of drugs, patients, designs, terms of study phases, and inconsistent clinical outcomes.
