ACTION Biomarker Study
Fiona A. Hagenbeek, Jenny van Dongen, Peter J. Roetman, Erik A. Ehli, Meike Bartels, Robert R. J. M. Vermeiren, Dorret I. Boomsma, ACTION Consortium
childhood aggression
childhood behavior problems
mental health
buccal cells
urine
genetics
epigenetics
DNA methylation
biomarkers
metabolomics
amines
organic acids
steroid hormones
multi-omics
Abstract
The goal of ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies) was to identify precursors, features, and consequences of childhood aggression using epidemiological and omics-driven studies. A considerable effort within ACTION was the collection of new omics data in children with low and high aggressive behavior. To this end, the ACTION project included large-scale collection of biological samples in children from the Netherlands Twin Register (NTR), a twin cohort from the general population, and a cohort of children referred for psychiatric treatment (LUMC-Curium). Together these cohorts comprise the ACTION Biomarker Study. This documentation describes the study design and data collection for the ACTION Biomarker Study.
