实验方法库

Brian D. Cosgrove, Lexi Bounds, Carson Key Taylor, Alan L. Su, Anthony J. Rizzo, Alejandro Barrera, Andrea R Daniel, Gregory E. Crawford, Brenton D. Hoffman, Charles A. Gersbach

2024-08-09

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Single cell CRISPRi screen to identify mechanoenhancer gene targets

CRISPRi

enhancer

extracellular matrix

mechanoenhancer

cell growth and migration

ECM

matrix stiffness

single cell RNA-seq

Brian D. Cosgrove, Lexi R. Bounds, Carson Key Taylor, Alan L. Su, Anthony J. Rizzo, Alejandro Barrera, Andrea R Daniel, Gregory E. Crawford, Brenton D. Hoffman, Charles A. Gersbach

2024-08-09

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Systematic Perturb-seq to discover endothelial cell programs related to CAD

Perturb-seq

scRNA-seq

endothelial cells

coronary artery disease

GWAS

variant-to-function

consensus non-negative matrix factorization

CRISPRi

Gavin R. Schnitzler, Helen Kang, Glen Munson, Philine Guckelberger, Drew Bergman, Brian Cleary, Eric S. Lander, Jesse Engreitz, Rajat M. Gupta

2024-01-19

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Programmable Gene Knockdown in Diverse Bacteria Using Mobile-CRISPRi

Bacillus subtilis

biofuels

conjugation

CRISPR-Cas9

CRISPRi

Escherichia coli

ESKAPE pathogens

functional genomics

Listeria monocytogenes

Zymomonas mobilis

Amy B. Banta, Ryan D. Ward, Jennifer S. Tran, Emily E. Bacon, Jason M. Peters, Amy B. Banta, Ryan D. Ward, Jennifer S. Tran, Emily E. Bacon, Jason M. Peters

2020-12-17

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